For my last post, my one bit of research, and I use this term lightly, was to link to a definition of tolerance. That led me to an interesting site.
There I found an interesting article related to relapse. They’ve found that neurogenesis, that is the generation of new nerve cells in the brain, may lead indirectly to context-driven-relapse.
“New findings from our lab show that neurogenesis—the generation of new neurons in the adult brain—in the hippocampus may strengthen memories tied to drug-seeking behavior in rodents with methamphetamine addiction-like behavior,” says Dr. Chitra Mandyam, senior investigator of the two studies. These findings suggest new approaches for reducing relapse risk. Says Dr. Mandyam, “We also demonstrated that inhibiting neurogenesis during abstinence with a small synthetic molecule prevented context-driven drug-seeking.”
They link to two recent studies so this seems legit. I suggest reading the article itself. It is quite technical but not too much, if I can follow it… What I didn’t follow was how long a period of abstinence they mean, but presumably it is the short term, as in early recovery.
They go on to describe drugs that can help by preventing neurogenesis, but I gather this is still in the early phase of testing. Still, I like to keep my mind active by mostly reading and learning new things. The idea of preventing new brain cells seems like a bad one to me (simply because neurogenesis is an expected effect of brain stimulation, which is important to me because I try to keep my brain active and thus hopefully “young”), but at least this mechanism whereby we are prone to drug-seeking behaviour due to memories when new brain cells form, is something to be cognizant of. The real work for me at the beginning of recovery was to keep my mind on other things, to be aware of my cravings but not act on them, and then eventually the interest to get drugs went away. This for me simply emphasizes how important it is to remain in control and avoid temptation in early recovery. After that, my opinion vs others related to addiction treatment diverges somewhat, since I don’t believe one need make any effort after the first few weeks. I didn’t. (Of course my experience was subjective. When I tried to quit a few years before, I relapsed after nine months, so saying “the first few weeks” might seem unreasonable. That’s just the way it went for me when I had made up my mind to stay clean for good. So it might be prudent to apply greater discipline in say… the first year.)
Here are the sources for the article:
- Galinato, M.H., Takashima, Y., Fannon, M.J., et al. Neurogenesis during abstinence is necessary for context-driven methamphetamine-related memory. Journal of Neuroscience 38(8):2029-2042, 2018.
- Galinato, M.H., Lockner, J., Fannon, M.J., et al. A synthetic small molecule isoxazole-9 protects against methamphetamine relapse. Molecular Psychiatry 23(3):629-638, 2018.